Ranitidine HCL API

We are offering high quality of Ranitidine HCL. We are known for manufacturing, exporting, distributing, trading and supplying Ranitidine HCL in Gujarat, India. Further, this is safely packaged by our professionals in diverse packaging options that maintain its purity and effectiveness.Shreeji Pharma International is leading Manufacturer, Exporter, Distributor, and Supplier Ranitidine HCL in Gujarat. India. Shreeji Pharma International manufacturing & gmp; supplying all products under GMP site with all types of regulatory supports.Shreeji Pharma International is the largest manufacturer, Exporter and supplier of Ranitidine HCL. Nowadays Shreeji Pharma International is one of the leading manufacturer and exporter, who is manufacturing Ranitidine HCL as well as Intermediates of Ranitidine HCL. Shreeji Pharma International is exporter, supplier, distributor and manufacturers of the Active Pharmaceuticals Ingredients in many countries for many years.Shreeji Pharma International currently exports Ranitidine HCL to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAM countries, Central American Countries and in European countries.Ranitidine Hydrochloride (HCl) is a histamine-2 (H₂) receptor antagonist (H₂ blocker) used to reduce stomach acid production. It was widely prescribed for conditions like gastroesophageal reflux disease (GERD), peptic ulcers, Zollinger-Ellison syndrome, and acid indigestion. However, due to concerns over N-nitrosodimethylamine (NDMA) contamination, its use has been banned or restricted in several countries.Chemical Properties:Chemical Name: N-(2-[(5-[(Dimethylamino)methyl]furan-2-yl)methylthio]ethyl)-N'-methyl-2-nitroethene-1,1-diamine hydrochlorideMolecular Formula: C₁₃H₂₂N₄O₃S·HCl Molecular Weight: 350.87 g/molCAS Number: 66357-59-3 Appearance: White to pale yellow crystalline powderSolubility: Freely soluble in water, alcohol, and methanolMelting Point: ~140°C Stability: Sensitive to heat, light, and moistureMechanism of Action: Blocks histamine (H₂) receptors in the stomach, reducing acid secretion.Lowers basal and stimulated gastric acid production, aiding ulcer healing and reflux control.Absorption: Rapid, peak plasma concentration in 2-3 hours.Bioavailability: ~50% (due to first-pass metabolism). Metabolism: Metabolized in the liver (partial metabolism). Half-life: ~2-3 hours.Excretion: Primarily via urine (~30-40% unchanged). Therapeutic Uses & Indications: Gastroesophageal Reflux Disease (GERD)Peptic Ulcers (Duodenal & Gastric Ulcers)Zollinger-Ellison Syndrome (Hyperacid Secretion Disorder) Erosive Esophagitis Dyspepsia & Acid IndigestionDosage & Administration: Usual adult dose: 150 mg twice daily or 300 mg once daily (bedtime).Pediatric dose: 2-4 mg/kg/day, divided into two doses. Route: Oral tablets, syrup, injectable forms (IV/IM).Side Effects: Common: Headache, dizziness, diarrhea, constipation.Serious: Liver toxicity (elevated liver enzymes, jaundice).Blood disorders (thrombocytopenia, leukopenia - rare).CNS effects (confusion, hallucinations in elderly patients).NDMA Contamination Concerns:Potential carcinogenic risk led to market withdrawal in many regions.Precautions & Contraindications:Long-term users (risk of vitamin B12 deficiency). Pregnant & breastfeeding women (use only if necessary).Drug About the Company GST Registration Date: 2017 Legal Status of Firm: Partnership Number of Employees: Upto 10 People Annual Turnover: 25 - 100 Cr