Future Beyond Polymers Polymers (Durable or Biocompatible) are an integral part of Drug Release Matrix in current generation DES as they ensure the Release Kinetics of the active drug, the critical determinant of antirestenotic efficacy. However, the mechanical properties of the Metallic Cage and Aggressive Inflammatory Reactions during polymer erosion are known to cause. Persistent Fibrin Deposition Delayed Endothelialisation Chronic Inflammation Persistent Platelet Activation Current DES Polymers are often associated with Flaking, Webbing and Peeling which leads to impaired action of active drug. VIVO ISAR is an innovative technology which eliminates the use of Polymer by using Dual Drug Technology: Sirolimus and Probucol Sirolimus:It is a well-studied and clinically proven Immunosuppressant. It inhibits activation of T cells and B cells by reducing their sensitivity to interleukin-2 (IL-2) through mammalian target of rapamycin inhibition (mTOR).Probucol: It is historically proven to impose anti-restenosis effects through anti-oxidative and direct anti-proliferative effects. Though in VIVO ISAR, it is not used as an Active Pharmaceutical Ingredient. Probucol here mimics the role of a Polymer thus functioning as a drug carrier. Probucol is used as a Matrix-Builder for the controlled release of Sirolimus. Probucol binds the drug on the stent and its properties of being hydrophobic and anti-oxidative, facilitates a controlled and continuous drug release. ResourcesProduct Brochure 10 years follow up clinical data of safety and efficacy in 3002 patients is published in Journal of American College of Cardiology. In the long-term analysis at 10 years (ISAR TEST 5 trial), Polymer-free VIVO ISAR showed numerically low rates of all-cause mortality, TVR, MI and Stent Thrombosis versus DP-ZES in the subset of diabetes mellitus. World's Longest Studied Drug Eluting Stent Even with no polymer, VIVO ISAR showed similar results with regards to safety and efficacy when compared with DES with permanent polymer in ACS patient subset In this long term analysis at 10 years, Polymer Free Vivo ISAR in Diabetic patients showed numerically low rates of all-cause mortality, TVR MI, and stent thrombosis versus DP-ZES In this long term analysis at 10 years , Polymer Free Vivo ISAR showed similar efficacy and safetyprofile as PP-ZES At 5 years, outcomes of patients treated with Vivo Isar compared with durable polymer-based ZES were similar in the subgroup of STEMI. At 5 years in diabetic patient subset , outcomes of patients treated with Vivo Isar compared with PP-ZES were similar At 5 years, Vivo Isar with no polymer demonstrates similar rates of definite/probable stentthrombosis as PP-ZES At 2 years, Vivo Isar demonstrated 43% reduction in binary restenosis in comparison to PP-ZES and23% reduction in comparison to PP-SES In preclinical study , Vivo Isar demonstrated ideal drug release kinetics and better endothelialisationas compared to polymer based and conventional polymer free stent. A rough stent surface does not increase late lumen loss after stent implantation as compared with a conventional smooth stent surface. About the Company Legal Status of Firm: Proprietorship Number of Employees: 11 To 25 People Annual Turnover: 25 - 100 Cr company-description: In our range of products, we are engaged in manufacturing, exporting and supplying Ophthalmic Forceps, Ophthalmic Scissors, Ophthalmic Instruments, Ophthalmic Diagnostic Equipments, Intraocular Lenses Implants, Surgical Drapes, Medical Grade Bulbs, PTCA Angioplasty Guide Wires and Interventional Cardiology Products of utmost quality. Our complete product array is manufactured using optimum quality raw material that is sourced from the reliable and trusted vendors of the industry. In Interventional Cardiology we are the authorized distributors for the following companies: Abbott Vascular. Cordis. Codman. Ethicon Suture. Terumo. Teleflex( Weck-USA) Bard( USA) Asahi (Japan) Merit Medical(usa)
